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KMID : 0043319990220010044
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Archives of Pharmacal Research
1999 Volume.22 No. 1 p.44 ~ p.47
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Synthesis and Analgesic and Anti-inflammatory Activities of 1,2-Benzothiazine Derivatives
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Lee Eun-Bang
Kwon Soon-Kyoung
Kim Sang-Geon
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Abstract
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Three 1,2-benzothiazine derivatives were synthesized, and their analgesic / anti-inflammatory efficacy and their effect s of gastric irritation were evaluated. Among the three compounds, 39 exhibited the most potent anlagesic action, but the effect was weaker than that of piroxicam. Nonetheless, the compound showed 4 times more potent analgesic action with less gastric damage than did ibuprofen. These compounds did not show anti-inflammatory effect at an oral dose of 5 mg/kg.
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KEYWORD
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1,2-Benzothiazine derivatives, Analgesic action, Gastric mucosal damage
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